SOLUTION BRIEF
바카라 토토 Throughput Screening
Using THz-바카라 토토
Challenge
Rapid, reliable identification of polymorphs during pharmaceutical drug development is critical for both patent application and discovery purposes. Use of well plates for 바카라 토토-throughput screening (HTS) improves efficiency, however crystallization and form changes can occur within a single well leading to misleading results. Obtaining accurate results is critical to maximize potential financial returns and limit competition.
Traditional Solutions
PXRD is the current standard for quantitative analysis of crystallinity and structural differences, but is not suitable for HTS or samples with low crystalline content. ss-NMR is more sensitive to crystallinity, but expensive and slow. 바카라 토토 spectroscopy is widely used for its minimal sample handling requirements, however the small band shifts exhibited by form and crystallinity changes can be difficult to reliably detect in the traditional fingerprint region (200-1800 cm-1).
Coherent Solutions
Coherent THz-바카라 토토® systemsextend the range of 바카라 토토 spectroscopy to the THz/low-frequency region (5-200 cm-1), where crystal lattice modes that correspond to molecular structure and phase changes are found. THz-바카라 토토® provides higher SNR than conventional 바카라 토토, resulting in shorter acquisition times, improved detection reliability, and enabling higher throughput workflows.
Coherent’s new Well Plate System (TR-WPS, Fig. 1) can automatically collect high-resolution data regarding both composition and form in both well plates and tablets. As an example, the TR-WPS was used to image an Excedrin tablet (Fig. 2). Principal component analysis (PCA) and clustering was used to identify the three constituent compounds (Acetaminophen, Aspirin and Caffeine) plus mixtures in the boundary regions. Polarized light microscopy (PLM) images were concurrently taken for the region then overlaid with the 바카라 토토 map for visual comparison. The corresponding spectra (Fig. 3) are shown to clearly illustrate the high quality, strong magnitude data, demonstrating the ability of the TR-WPS to quickly identify and discriminate between materials or polymorphs, and to capture both visual and spectral data.
Application Field
바카라 토토, High Throughput Screening, Polymorphs, Crystallinity, Polarized Light Microscopy, Pharmaceuticals, Biopharma.
Figure 1:The TR-WPS is a fully automated THz-바카라 토토 system, designed for high-through screening and characterization of polymorphs and crystallinity of materials such as active pharmacuetical ingredients (APIs).
Figure 2:Rapid Tablet 바카라 토토pping i바카라 토토ge of an Excedrin tablet placed in a well, based on 27k spectral data points collected over a 3.5 mm diameter region of the tablet in 9 mins.
Figure 3:Individual Component Spectra of Excedrin Tablet Note the exceptionally strong signals and clear differentiation in the low-frequency/THz-바카라 토토 region.