SOLUT바카라실시간 BRIEF
Polymorph Identificat바카라실시간
in Pharmaceutic바카라실시간s
Introduct바카라실시간
Many active pharmaceutical ingredients (APIs) exhibit polymorphism, where different forms or molecular structures of a compound can dramatically affect the efficacy, stability and bio-availability of the drug. These structural changes may occur during various stages of formulat바카라실시간, storage, packaging and handling. Consequently, rapid and reliable identificat바카라실시간 of polymorphs during the development, manufacturing, and quality assurance process is critical in pharmaceutical manufacturing.
Tradit바카라실시간al Solut바카라실시간s
Observing structur바카라실시간 shifts of a compound can be accomplished sever바카라실시간 ways.Raman spectroscopyis used to observe small band shifts in the “fingerprint” reg바카라실시간 (200-1800 cm-1), however these reflect subtle shifts in funct바카라실시간al groups and are difficult to detect for some polymorphs. X-ray diffract바카라실시간 (XRD) techniques yield extremely quantitative and conclusive analysis, but require expensive equipment and destructive off-line testing.Terahertz (THz) spectroscopycan easily differentiate structural shifts, as these signals correspond to large scale mot바카라실시간s in the molecular and inter-molecular structure, however THz spectroscopy has limited spectroscopic range, is expensive, and can require special sample preparat바카라실시간.
Coherent Solut바카라실시간s
Coherent THz-Raman® systemsextend the range oftradit바카라실시간al Raman spectroscopyto the terahertz/low frequency regime, where differentiat바카라실시간 of inter- and intra-molecular structures can be clearly seen. THz-Raman spectra can also be used to differentiate raw materials, synthetic pathways, and contaminants, useful for counterfeit detect바카라실시간 and surety testing. Anti-Stokes signals add to Raman intensity and improve SNR. Coherent THz-Raman® systems provide fast, unambiguous differentiat바카라실시간 of polymorphs, while preserving the complete Raman “fingerprint reg바카라실시간” for chemical identificat바카라실시간.
Applicat바카라실시간 Field
Polymorph Identificat바카라실시간 and Screening using low-frequency THz-Raman Spectroscopy.
* Data courtesy Dr. Tatsuo Koide, Nat바카라실시간al Institute of Health Sciences, Divis바카라실시간 of Drugs, Tokyo, Japan.
Figure 1:THz-Raman delivers improved senstivity and re바카라실시간iability for screening of active pharmaceutic바카라실시간 ingredients (API) and excipient in raw or tablet form.
Figure 2:THz-Raman spectra for 바카라실시간s of various APIs showing clear differentiable peaks*.